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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018
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Results from this study suggest that hepatic fat export in periparturient dairy cows is improved by choline supplementation during the transition period and this may potentially decrease the risk for metabolic disorders in the periparturient dairy cow.”12 Choline is also known to be involved in the synthesis of carnitine, cell membrane phospholipids, and the neurotransmitter acetylcholine
