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On the other hand, rab 3-like peptides have been shown to stimulate exocytosis via a PtX-sensitive G protein when applied extracellularly (Law et al., 1993)

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Figure 2 Several studies in recent years have shown that silencing TRFC (the gene encoding TFR1) inhibits erastin-induced iron apoptosis and prevents LIP accumulation, whereas the heme oxygenase HO-1 increases intracellular free iron levels and promotes heme degradation, which speeds up the ferroptosis process (78, 79)