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According to NICE guideline NG12, urgent referral for suspected cancer should be considered for people with: Dysphagia (difficulty swallowing) at any age Aged 55 and over with weight loss and upper abdominal pain, reflux, or dyspepsia Unexplained iron-deficiency anaemia Evidence of gastrointestinal bleeding Children and adolescents should only use zinc L-carnosine under professional guidance, as safety and appropriate dosing have not been established for paediatric populations

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While historically less common on the U.S