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In addition, there is no scientific evidence demonstrating that glutamine supplementation can suppress and/or inhibit permanently its endogenous production or de novo synthesis

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As glutathione can improve the numbers and activity of macrophages, peptic ulcers may be exacerbated [40] Increased susceptibility to melanoma: Theoretically, long-term administration of systemic glutathione switches eumelanin to pheomelanin, and may increase the susceptibility towards development of melanoma in the long run