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1 Introduction Hepatocellular carcinoma (HCC) is the most frequent malignant tumor of the liver, with the highest occurrence among people with chronic liver disease ( Ferroptosis is an iron-dependent controlled cell death caused by polyunsaturated fatty acid-containing phospholipids (PL-PUFA) in cell membranes that differentiates from other types of cell death by iron-dependent accumulation of lipid peroxides and redox imbalance ( 2 The mechanism of ferroptosis The rise in ROS surpasses the regulating capacity of glutathione (GSH) and GPX 4, resulting in lipid peroxidation ( Figure 1 )

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At present, increasing evidence has shown that compounds derived from natural medicines exert a variety of beneficial effects, including antioxidant, anti-inflammatory, and anti-apoptosis effects [119,120,121]