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on nanogels, NGs prepared using β-lactoglobulin, reconstituted silk fibroin, and lysozyme showed remarkable intracellular penetration ability as well as delivery of intracellular cargo (Toprakcioglu et al., 2020) Preparation and Applications of Protein-Based Nanohydrogels (NG) Nanohydrogels comprising of natural biomaterials are commonly prepared from natural proteins/peptides derived from animal or plant resources and polysaccharide polymers such as hyaluronic acid, chitosan, heparin, alginate, and agarose, etc