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Although some of the natural ingredients used in these patches, such as berberine, have shown in some studies to slightly increase GLP-1 levels, regulate blood sugar levels and promote weight loss 8 , their efficiency through transdermal methods is not yet proven and needs to be studied further 3

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Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice