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Note, a reduction in bodyweight, RV hypertrophy, and an increase in RV weight still occur when treatment involves a endothelin receptor antagonist (e.g., macitentan) [22,23,78], and thereby, the underlying pathogenesis of the monocrotaline model continues to progress, and pulmonary hypertension continues to develop despite the treatment [21], unlike the noted elimination in the BPC 157 regimens

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