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The oxidative stress results in elevated oxyradical generation, protein and other macromolecular oxidation, and finally leads to different diseases (Everse & Coates, 2005)

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Once oxidized during ROS detoxification (most notably through glutathione peroxidase–mediated reduction of hydrogen peroxide), glutathione must be regenerated from its oxidized form (GSSG) by glutathione reductase, a process dependent on a continuous supply of NADPH from the pentose phosphate pathway (3)