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Initially EpRE was called the antioxidant response element (ARE) because the first compound, shown to activate ARE was a so-called antioxidant that was subsequently shown to generate H 2 O 2 through redox cycling (Pinkus et al., 1996)

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Statements Data availability statement The original contributions presented in this study are included in this article/supplementary material, further inquiries can be directed to the corresponding author