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The cortical thickness at the pre and postcentral gyrus, and insula correlated with measures of nerve conduction

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It is activated in response to inflammatory stimuli such as IL-17A, IL-1β (134, 148), bacterial LPS (149), or growth factors (e.g., VEGF, EGF) (150) Excessive activation of this pathway can lead to pathological inflammatory conditions, including psoriasis, rheumatoid arthritis, and Crohn’s disease (151, 152)