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Researchers should select between these analogs based on whether their experimental question requires localized, pulsatile signaling (IGF-1 DES) or sustained, systemic signaling (IGF-1 LR3)

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Taken together, these findings demonstrate that MITOL-dependent HMOX2 regulation in C2C12 cells is essential for the supply of haem-derived iron to mitochondria, ensuring mitochondrial respiratory supercomplex formation, which is critical for cell proliferation

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