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Other sources of superoxide include enzymatic reactions that transfer electrons to the electron transport chain (eg, mitochondrial glycerol 3-phosphate dehydrogenase (mGPDH), and the last step of Ξ²-oxidation, electron-transferring flavoprotein ubiquinone oxidoreductase (ETFQOR), pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH), and branched-chain 2-oxoacid dehydrogenase (BCKDH))
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Thus, by altering the RANKL/OPG ratio, TNF-Ξ± enhances bone resorption, contributing to osteoporosis progression
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