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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range.¹⁰ Reaching 15 mg is not the problem

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Most peptide regimens used in obesity and metabolic research show good overall tolerability, but they still carry risks, particularly for patients with diabetes, cardiovascular disease, or cancer history