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Proc Natl Acad Sci U S A 97: 11482–11487, 2000 [DOI] [PMC free article] [PubMed] [Google Scholar] 73.Gorressen S, Stern M, van de Sandt AM, Cortese-Krott MM, Ohlig J, Rassaf T, Godecke A, Fischer JW, Heusch G, Merx MW, and Kelm M

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The effects are not as good as oral supplementation, & we do not routinely add this to your melasma or skin lightening program