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20%) had no effect on either the Cys-151 or the Cys-226/Cys-613 sensors, and knockdown of TXNRD1 resulted in just modest stabilization of the Cys-151–Cys-151 and Cys-226–Cys-613 disulfide bridges [251]

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At the 15mg dose, more than half of all participants lost 20% or more of their body weight