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To confirm that weight loss in the setting of cysteine deficiency is due to the concurrent induction of the ISR and OSR, we fed mice a no-Trp diet while administering l-buthionine sulfoximine (BSO), a specific inhibitor of γ-glutamyl cysteine synthase, which decreases GSH but not cysteine (Fig

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TABLE 1 Clinical summary of antioxidant intervention in ASD: Population, dose/route, duration, clinical domains, redox biomarkers, safety, and level of evidence are reported for each study