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[DOI] [PMC free article] [PubMed] [Google Scholar] 269.Zhao Z., Chen Y., Wang J., Sternberg P., Freeman M.L., Grossniklaus H.E., et al

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demonstrated that activation of the nuclear receptor FXR by BAs significantly suppresses ferroptosis by upregulating multiple ferroptosis gatekeepers, including GPX4, FSP1, PPARα, SCD1 and ACSL3 ( Furthermore, studies have confirmed the presence of physiologically relevant concentrations of BAs species in ovarian tissue, along with expression of FXR and BAs transporters ( 4.2.4 Lactic acid bacteria metabolites Lactic acid bacteria produce various metabolites, including 1,3-diaminopropane (DAP), reuterin, and 5-methoxyindoleacetic acid (5-MIAA)